{"id":1600,"date":"2025-11-26T08:05:18","date_gmt":"2025-11-26T08:05:18","guid":{"rendered":"https:\/\/charis.com.vn\/?p=1600"},"modified":"2025-11-26T08:05:18","modified_gmt":"2025-11-26T08:05:18","slug":"gan-nhiem-mo-lien-quan-den-roi-loan-chuyen-hoa-masld-va-viem-gan-nhiem-mo-mash","status":"publish","type":"post","link":"https:\/\/charis.com.vn\/en\/gan-nhiem-mo-lien-quan-den-roi-loan-chuyen-hoa-masld-va-viem-gan-nhiem-mo-mash\/","title":{"rendered":"METABOLIC FATTY LIVER DISEASE (MASLD) AND STEROID HEPATITIS (MASH)"},"content":{"rendered":"<p>Many people still think: &quot;Only drinking a lot of alcohol can cause liver disease&quot;. In fact, it is completely the opposite!<\/p>\n<p>In Vietnam, about 20\u2013251 TP3T adults have fatty liver (increased from ~101 TP3T to this level in the past 10 years), mainly due to the habit of eating a lot of starch, sweets, little exercise and increasingly &quot;hypertrophied&quot; waistline and &gt;901 TP3T not due to alcohol. This is <strong>non-alcoholic fatty liver disease<\/strong> \u2013 the new name globally is <strong>MASLD<\/strong> (fatty liver related to metabolic disorders) and when there is severe inflammation it is called <strong>MASH<\/strong>.<\/p>\n<ol>\n<li><strong> MASLD fatty liver and hepatitis<\/strong><strong> by<\/strong><strong> What is MASH fatty liver?<\/strong><\/li>\n<\/ol>\n<ul>\n<li><strong>MASLD<\/strong> (formerly known as NAFLD): a condition in which fat accumulates in the liver due to metabolic factors such as being overweight, high blood sugar, high blood lipids, high blood pressure.<\/li>\n<li><strong>MASH<\/strong> (formerly called NASH): when the liver is not only fatty but also <strong>inflammation<\/strong> and can leave scars (cirrhosis). This is a more serious stage, which can progress to cirrhosis or even liver cancer if not well controlled.<\/li>\n<\/ul>\n<p>If you have both metabolic fatty liver and drink a lot of alcohol, it is called <strong>MetALD<\/strong> (both reasons).<\/p>\n<ol start=\"2\">\n<li><strong> Who is susceptible? <\/strong><strong>Fatty liver disease<\/strong><strong>?<\/strong><\/li>\n<\/ol>\n<p>More than 80\u201390% of people with steatohepatitis have at least one of the following factors (usually a combination of factors):<\/p>\n<ul>\n<li>Overweight, obesity (especially abdominal fat)<\/li>\n<li>Type 2 diabetes or prediabetes (insulin resistance)<\/li>\n<li>High blood fat (high triglycerides, high bad cholesterol)<\/li>\n<li>High blood pressure<\/li>\n<\/ul>\n<p>The above quartet is called <strong>metabolic syndrome<\/strong> \u2013 \u201csoldiers\u201d often go together and are also the leading cause of severe fatty liver in our country today.<\/p>\n<ol start=\"3\">\n<li><strong> Common symptoms<\/strong><\/li>\n<\/ol>\n<p>Extremely \u201csilent\u201d! Most people <strong>no obvious symptoms<\/strong>. A few may see:<\/p>\n<ul>\n<li>Prolonged fatigue, lethargy<\/li>\n<li>Mild pain in the right subcostal region (liver area)<\/li>\n<li>Flatulence, indigestion<\/li>\n<\/ul>\n<p>Therefore, the disease is often only detected during a routine health check-up or abnormal blood test.<\/p>\n<ol start=\"4\">\n<li><strong> How do I know if I have it? <\/strong><strong>Fatty liver disease<\/strong><strong>?<\/strong><\/li>\n<\/ol>\n<p>The doctor will do a series of tests in the following order:<\/p>\n<ol>\n<li><strong>Testing <\/strong><strong>blood<\/strong>: Liver enzymes ALT, AST can increase slightly or clearly, but there are also cases where liver enzymes are normal even though the liver is inflamed (MASH).<\/li>\n<li><strong>Abdominal ultrasound<\/strong>: liver is bright (fatty), but ultrasound cannot distinguish between simple fatty liver or fatty hepatitis.<\/li>\n<li><strong>Liver stiffness measurement (FibroScan)<\/strong>: non-invasive method to know if the liver is severely cirrhotic or not.<\/li>\n<li><strong>Liver biopsy<\/strong> (rarely required): indicated when it is necessary to accurately determine the degree of inflammation and fibrosis, or when other causes are suspected (viral hepatitis, autoimmune...).<\/li>\n<\/ol>\n<ol start=\"5\">\n<li><strong> Treatment \u2013 What to do to make the liver healthy again?<\/strong><\/li>\n<\/ol>\n<p>The good news is: <strong>Fatty liver disease<\/strong><strong> It is possible to improve and even return to near normal.<\/strong> if we change our lifestyle properly.<\/p>\n<ol>\n<li><strong>A. Things to do immediately (most important)<\/strong><\/li>\n<\/ol>\n<ol>\n<li><strong>Lose weight slowly and sustainably<\/strong>\n<ul>\n<li>Lose 5\u201310% weight \u2192 liver fat is significantly reduced.<\/li>\n<li>It is best to lose 0.5\u20131 kg\/week (losing too quickly is harmful to the liver).<\/li>\n<li>Combine healthy eating + regular exercise 150 minutes\/week (brisk walking, cycling, swimming\u2026 are all fine).<\/li>\n<\/ul>\n<\/li>\n<li><strong>Control blood sugar, blood fat, blood pressure<\/strong>\n<ul>\n<li>Take medication regularly if you have diabetes or high blood fat (medications such as\u00a0<strong>Statins are generally safe and have superior benefits.<\/strong>, but need to be monitored regularly by a doctor).<\/li>\n<li>Eat bland food, reduce fried foods, limit white rice - cakes - soft drinks.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Limit alcohol completely<\/strong> (Alcohol is the &quot;number 1 enemy&quot; of an inflamed liver).<\/li>\n<li><strong>Vaccination<\/strong>\n<ul>\n<li>Hepatitis A, hepatitis B (if not immune) for additional liver protection.<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<ol>\n<li><strong>B. Current medications<\/strong><\/li>\n<\/ol>\n<ul>\n<li><strong>Vitamin E<\/strong> (800 IU\/day): sometimes doctors use it for people with severe fatty liver disease, without diabetes. However, <strong>This treatment dose must be prescribed by a specialist and closely monitored, do not use it on your own.<\/strong><\/li>\n<\/ul>\n<ul>\n<li><strong>Resmetirom<\/strong>: New drug approved by FDA 2024, under testing and not yet popular in Vietnam.<\/li>\n<\/ul>\n<ul>\n<li>Some diabetes medications (such as pioglitazone, semaglutide) are also very effective in reducing liver fat.<\/li>\n<\/ul>\n<ol start=\"6\">\n<li><strong> Prognosis \u2013 Is the disease dangerous?<\/strong><\/li>\n<\/ol>\n<ul>\n<li>Fortunately, most people with simple fatty liver will <strong>no progression<\/strong>, life expectancy is almost normal.<\/li>\n<\/ul>\n<ul>\n<li>About 10\u201325% people with fatty liver disease, if not controlled, will progress to cirrhosis after 10\u201320 years, or even liver cancer.<\/li>\n<\/ul>\n<p><strong>Great news<\/strong>: Just lose weight + exercise regularly, liver enzymes can return to normal in 3-6 months, and the risk of cirrhosis is greatly reduced!<\/p>\n<p><strong>Final advice from the doctor<\/strong><\/p>\n<p>The liver is the most \u201cgentle and grateful\u201d organ in the body. We just need to:<\/p>\n<ul>\n<li>Lose 5\u20137 kg (if overweight)<\/li>\n<li>Quit or reduce alcohol<\/li>\n<li>Exercise regularly, eat lots of vegetables and fish, and less bad starch.<\/li>\n<\/ul>\n<p>\u2192 The liver will have a great ability to regenerate itself.\u00a0<strong>This is the cornerstone of treatment, which may help reduce or delay the need for additional liver-specific medications.<\/strong>\u00a0However, medications to treat underlying diseases such as diabetes and hyperlipidemia still need to be maintained as prescribed.<\/p>\n<p>Go for regular check-ups every 6\u201312 months (blood tests, ultrasounds) for close monitoring.<\/p>\n<p>Wish everyone always have a healthy liver!<\/p>\n<p><strong>Dr. TRAN PHUONG THAO<\/strong>, <strong>USMLE Step 3, <\/strong>General Internal Medicine, Gastroenterology, Hepatobiliary<\/p>\n<p>&nbsp;<\/p>","protected":false},"excerpt":{"rendered":"<p>Nhi\u1ec1u ng\u01b0\u1eddi v\u1eabn ngh\u0129: \u201cCh\u1ec9 c\u00f3 u\u1ed1ng r\u01b0\u1ee3u bia nhi\u1ec1u m\u1edbi b\u1ecb b\u1ec7nh gan\u201d. Th\u1ef1c t\u1ebf th\u00ec ho\u00e0n to\u00e0n ng\u01b0\u1ee3c l\u1ea1i! T\u1ea1i Vi\u1ec7t Nam, kho\u1ea3ng 20\u201325% ng\u01b0\u1eddi tr\u01b0\u1edfng th\u00e0nh b\u1ecb gan nhi\u1ec5m m\u1ee1 (t\u0103ng t\u1eeb ~10% l\u00ean m\u1ee9c n\u00e0y trong 10 n\u0103m qua), ch\u1ee7 y\u1ebfu do th\u00f3i quen \u0103n nhi\u1ec1u tinh b\u1ed9t, \u0111\u1ed3 ng\u1ecdt, \u00edt [&hellip;]<\/p>","protected":false},"author":3,"featured_media":1601,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-1600","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>GAN NHI\u1ec4M M\u1ee0 LI\u00caN QUAN \u0110\u1ebeN R\u1ed0I LO\u1ea0N CHUY\u1ec2N H\u00d3A (MASLD) V\u00c0 VI\u00caM GAN NHI\u1ec4M M\u1ee0 (MASH) - Charis Healthcare<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/charis.com.vn\/en\/gan-nhiem-mo-lien-quan-den-roi-loan-chuyen-hoa-masld-va-viem-gan-nhiem-mo-mash\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"GAN NHI\u1ec4M M\u1ee0 LI\u00caN QUAN \u0110\u1ebeN R\u1ed0I LO\u1ea0N CHUY\u1ec2N H\u00d3A (MASLD) V\u00c0 VI\u00caM GAN NHI\u1ec4M M\u1ee0 (MASH) - Charis Healthcare\" \/>\n<meta property=\"og:description\" content=\"Nhi\u1ec1u ng\u01b0\u1eddi v\u1eabn ngh\u0129: \u201cCh\u1ec9 c\u00f3 u\u1ed1ng r\u01b0\u1ee3u bia nhi\u1ec1u m\u1edbi b\u1ecb b\u1ec7nh gan\u201d. 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Th\u1ef1c t\u1ebf th\u00ec ho\u00e0n to\u00e0n ng\u01b0\u1ee3c l\u1ea1i! 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